a transformation-incompetent, nuclear antigen 2-deleted epstein-barr virus associated with replicative infection.

NLM AIDSLINE A transformation-incompetent, nuclear antigen 2-deleted Epstein-Barr virus associated with replicative infection. Sixbey JW; Shirley P; Sloas M; Raab-Traub N; Israele V; Department of
August 30, 1991

J Infect Dis. 1991 May;163(5):1008-15. Unique Identifier : AIDSLINE Epstein-Barr virus (EBV) obtained directly from the oropharynx was used to detect viral DNA deleted for the EBV nuclear antigen 2 (EBNA2)-encoding gene that is essential for lymphocyte transformation. By polymerase chain reaction analysis, the deletion was found in virus from 5 of 33 healthy adult donors and 11 of 12 patients with concurrent human immunodeficiency virus infection. Lymphoblastoid cell lines that produce standard transforming EBV also harbored EBNA2-deleted virus in cells permissive of EBV replication. In vitro infectivity studies indicated that the DNA is packaged and transmissible, with biologic properties similar to those of a laboratory mutant, P3HR-1, which also lacks the EBNA2 gene. These findings, obtained from productively infected cell systems, provide evidence for the existence in nature of a transformation-incompetent EBV variant that may facilitate EBV persistence and the emergence of reactivation diseases. Antigens, Viral/GENETICS Base Sequence Cell Line Cell Nucleus/IMMUNOLOGY Cell Transformation, Viral Chromosome Deletion DNA, Viral/ANALYSIS/CHEMISTRY Herpesviridae Infections/MICROBIOLOGY Herpesvirus 4, Human/*GENETICS/IMMUNOLOGY/PHYSIOLOGY Human Molecular Sequence Data Mutation Nucleic Acid Hybridization Oropharynx/MICROBIOLOGY Polymerase Chain Reaction Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Virus Replication JOURNAL ARTICLE

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Information in this article was accurate in August 30, 1991. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.