Virology. 1991 May;182(1):397-402. Unique Identifier : AIDSLINE
Simian immunodeficiency viruses from African green monkeys (SIVagm) are
the most genetically heterogeneous type of non-human primate lentivirus.
To further examine the extent of genetic divergence within the SIVagm
type, we generated and sequenced a biologically active proviral DNA
clone representing a lentivirus isolated from a distinct African green
monkey species (grivet). Overall, this clone (gri-1/lambda II) was
highly divergent from previously characterized SIVagm clones.
Specifically, the difference between gri-1/lambda II and other SIVagm
clones approximated the difference between the caprine arthritis
encephalitis virus and visna virus (two biologically and genetically
distinct ruminant lentiviruses). Our data suggest that lentiviruses from
African green monkeys may have evolved in concert with speciation of the
genus and support the concept that SIVagm may be the oldest primate
lentivirus type in existence.
Amino Acid Sequence Animal Cercopithecus aethiops/*MICROBIOLOGY
Cloning, Molecular Comparative Study DNA, Viral/*GENETICS Gene
Products, rev/GENETICS Gene Products, tat/GENETICS Gene Products,
vif/GENETICS Molecular Sequence Data Support, U.S. Gov't, P.H.S.
SIV/*GENETICS Viral Proteins/GENETICS JOURNAL ARTICLE