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A highly divergent proviral DNA clone of SIV from a distinct species of African green monkey.


Virology. 1991 May;182(1):397-402. Unique Identifier : AIDSLINE

Simian immunodeficiency viruses from African green monkeys (SIVagm) are the most genetically heterogeneous type of non-human primate lentivirus. To further examine the extent of genetic divergence within the SIVagm type, we generated and sequenced a biologically active proviral DNA clone representing a lentivirus isolated from a distinct African green monkey species (grivet). Overall, this clone (gri-1/lambda II) was highly divergent from previously characterized SIVagm clones. Specifically, the difference between gri-1/lambda II and other SIVagm clones approximated the difference between the caprine arthritis encephalitis virus and visna virus (two biologically and genetically distinct ruminant lentiviruses). Our data suggest that lentiviruses from African green monkeys may have evolved in concert with speciation of the genus and support the concept that SIVagm may be the oldest primate lentivirus type in existence.

Amino Acid Sequence Animal Cercopithecus aethiops/*MICROBIOLOGY Cloning, Molecular Comparative Study DNA, Viral/*GENETICS Gene Products, rev/GENETICS Gene Products, tat/GENETICS Gene Products, vif/GENETICS Molecular Sequence Data Support, U.S. Gov't, P.H.S. SIV/*GENETICS Viral Proteins/GENETICS JOURNAL ARTICLE


Information in this article was accurate in August 30, 1991. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.