J Rheumatol. 1991 Feb;18(2):297-9. Unique Identifier : AIDSLINE
A 60-year-old woman was admitted to our hospital with symmetrical
arthritis of the knees. During the 2 years preceding admission, she had
experienced recurrent arthritis. A histological examination of her
synovial tissue showed prominent villous proliferation of the synovial
cells, prominent vascularity throughout and an inflammatory infiltrate
composed of abnormal mononuclear cells. Three months later, she
developed fever, skin eruptions, lymphadenopathy and hepatosplenomegaly.
She also had hypercalcemia and there was abnormal lymphocytosis in her
blood smears. She was diagnosed as having adult T cell leukemia.
Parenteral chemotherapy treatment with adriamycin and cyclophosphamide
gave remission of all the manifestations of disease, including
arthritis. Her leukemia recurred, however, and she died 6 months after
the diagnosis was made.
Antineoplastic Agents, Combined/THERAPEUTIC USE Case Report Cell
Division/PHYSIOLOGY Cyclophosphamide/ADMINISTRATION & DOSAGE
Doxorubicin/ADMINISTRATION & DOSAGE Female Human HTLV-I/PHYSIOLOGY
Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated/DRUG THERAPY/
*ETIOLOGY/PATHOLOGY Middle Age Monocytes/PATHOLOGY Synovial
Fluid/CYTOLOGY Synovial Membrane/PATHOLOGY
Synovitis/*COMPLICATIONS/PATHOLOGY JOURNAL ARTICLE