J Clin Invest. 1991 May;87(5):1710-5. Unique Identifier : AIDSLINE
The mechanisms by which HIV-1 infection kills T lymphocytes are not
clearly established. Apoptosis is an internally programmed cell death
pathway that may regulate both T cell development and senescence, and
that is characterized by cleavage of DNA at internucleosomal regions.
The present experiments show that acute HIV-1 infection of MT2
lymphoblasts and activated normal peripheral blood mononuclear cells
induces apoptosis. The addition of anti-gp120 neutralizing antibody,
after HIV-1 infection of MT2 cells, permitted sustained high levels of
viral replication, but blocked apoptosis and cell death. Apoptosis may
account for the direct cytopathologic effects of HIV-1 in T cells.
Antigens, CD4/PHYSIOLOGY Calcium/METABOLISM *Cell Survival Cells,
Cultured DNA/METABOLISM Human HIV Envelope Protein gp120/METABOLISM
HIV Infections/PATHOLOGY *HIV-1/PHYSIOLOGY Nucleosomes/METABOLISM
Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. Support, U.S.
Gov't, P.H.S. T-Lymphocytes/MICROBIOLOGY/*PATHOLOGY JOURNAL ARTICLE