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Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1.


J Clin Invest. 1991 May;87(5):1710-5. Unique Identifier : AIDSLINE

The mechanisms by which HIV-1 infection kills T lymphocytes are not clearly established. Apoptosis is an internally programmed cell death pathway that may regulate both T cell development and senescence, and that is characterized by cleavage of DNA at internucleosomal regions. The present experiments show that acute HIV-1 infection of MT2 lymphoblasts and activated normal peripheral blood mononuclear cells induces apoptosis. The addition of anti-gp120 neutralizing antibody, after HIV-1 infection of MT2 cells, permitted sustained high levels of viral replication, but blocked apoptosis and cell death. Apoptosis may account for the direct cytopathologic effects of HIV-1 in T cells.

Antigens, CD4/PHYSIOLOGY Calcium/METABOLISM *Cell Survival Cells, Cultured DNA/METABOLISM Human HIV Envelope Protein gp120/METABOLISM HIV Infections/PATHOLOGY *HIV-1/PHYSIOLOGY Nucleosomes/METABOLISM Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't, P.H.S. T-Lymphocytes/MICROBIOLOGY/*PATHOLOGY JOURNAL ARTICLE


Information in this article was accurate in August 30, 1991. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.