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NLM AIDSLINE

Molecular basis of latency in pathogenic human viruses.




 

Science. 1991 Nov 8;254(5033):815-20. Unique Identifier : AIDSLINE

Several human viruses are able to latently infect specific target cell populations in vivo. Analysis of the replication cycles of herpes simplex virus, Epstein-Barr virus, and human immunodeficiency virus suggests that the latent infections established by these human pathogens primarily result from a lack of host factors critical for the expression of viral early gene products. The subsequent activation of specific cellular transcription factors in response to extracellular stimuli can induce the expression of these viral regulatory proteins and lead to a burst of lytic viral replication. Latency in these eukaryotic viruses therefore contrasts with latency in bacteriophage, which is maintained primarily by the expression of virally encoded repressors of lytic replication.

Herpesvirus 4, Human/PHYSIOLOGY/PATHOGENICITY Human HIV-1/PHYSIOLOGY/PATHOGENICITY Models, Biological Simplexvirus/PHYSIOLOGY/PATHOGENICITY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Viruses/*PHYSIOLOGY/PATHOGENICITY JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL



 




Information in this article was accurate in February 28, 1992. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.