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Activation of the human immunodeficiency virus type 1 enhancer is not dependent on NFAT-1.


J Virol. 1992 Jun;66(6):3961-5. Unique Identifier : AIDSLINE

The function of a putative NFAT-1 site in the human immunodeficiency virus type 1 enhancer has been analyzed. Activation by the T-cell antigen receptor is minimal in Jurkat cells and is mediated by the kappa B sites. The putative NFAT-1 region is not required for the response to anti-CD3 or to mitogens in T-cell, B-cell, or monocyte/macrophage leukemia lines, nor is it a cis-acting negative regulatory element.

Antigens, Differentiation, T-Lymphocyte/IMMUNOLOGY Base Sequence Comparative Study DNA Mutational Analysis *Gene Expression Regulation, Viral Human HIV Enhancer/*GENETICS HIV-1/*GENETICS Leukocytes, Mononuclear/MICROBIOLOGY Macrophages/MICROBIOLOGY Mitogens/PHARMACOLOGY Molecular Sequence Data NF-kappa B/METABOLISM Receptors, Antigen, T-Cell/IMMUNOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Transcription Factors/*METABOLISM JOURNAL ARTICLE


Information in this article was accurate in August 30, 1992. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.