Resource Logo

Human immunodeficiency virus type 2 infection and fusion of CD4-negative human cell lines: induction and enhancement by soluble CD4.


J Virol. 1992 Jun;66(6):3531-7. Unique Identifier : AIDSLINE

We describe human immunodeficiency type 2 (HIV-2) strains which induce cell-to-cell fusion and infect certain CD4- human cell lines. Soluble CD4 (sCD4) induces or enhances fusion by most HIV-2 strains tested. Soluble CD4-immunoglobulin G chimeras and conjugates of sCD4 and antibody to the third domain of CD4 block HIV-2 fusion of CD4- cells. We conclude that HIV-2 can enter CD4- cells via an alternative cell surface receptor to CD4. While some strains entered efficiently, others retained a dependency on an interaction with sCD4 to initiate changes in the virion envelope required for membrane fusion.

Acquired Immunodeficiency Syndrome/*MICROBIOLOGY Antigens, CD4/*METABOLISM Cell Fusion/DRUG EFFECTS/*PHYSIOLOGY Cell Line DNA Mutational Analysis Human HIV Envelope Protein gp120/METABOLISM HIV-2/*PATHOGENICITY Receptors, HIV/METABOLISM Recombinant Fusion Proteins/METABOLISM Rhabdomyosarcoma/MICROBIOLOGY Support, Non-U.S. Gov't Tumor Cells, Cultured JOURNAL ARTICLE


Information in this article was accurate in August 30, 1992. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.