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The role of fiberoptic bronchoscopy for diagnosis of pulmonary tuberculosis in patients at risk for AIDS [see comments]




 

Chest. 1992 May;101(5):1211-4. Unique Identifier : AIDSLINE MED/92258112

In patients with acquired immunodeficiency syndrome (AIDS)-associated pulmonary Mycobacterium tuberculosis (MTB) (group 1), we analyzed whether the addition of transbronchial biopsy (TBB) and bronchial brushings augmented the diagnostic MTB yield over nonbiopsy sampling. Positive acid-fast bacilli (AFB) smears from combined sputum, bronchoalveolar lavage (BAL), and washings were 30 percent compared with 37 percent when brushings and TBB were added (p = NS). The addition of TBB increased culture yield from 96 percent to 100 percent (p = NS). Similar results were seen in patients with pulmonary MTB without human immunodeficiency virus (HIV) risk factors (group 2). Group 1 patients most commonly had a nonspecific inflammation on TBB histopathology and had a lower incidence of granuloma formation than group 2 (p less than 0.05). Our results suggest that more invasive sampling with bronchial brushings and TBB does not contribute to the microscopic, bacteriologic, or histopathologic diagnosis of pulmonary MTB, independent of AIDS risk factors.

Acquired Immunodeficiency Syndrome/*COMPLICATIONS Biopsy, Needle Bronchi/MICROBIOLOGY Bronchoalveolar Lavage Fluid *Bronchoscopy Human Mycobacterium tuberculosis/ISOLATION & PURIF Risk Factors Sputum/MICROBIOLOGY Tuberculosis, Pulmonary/COMPLICATIONS/*DIAGNOSIS JOURNAL ARTICLE



 




Information in this article was accurate in August 30, 1992. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.