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HIV-1 ancestry primordial expansions of RRE and RRE related sequences.


J Theor Biol. 1992 Feb 7;154(3):285-302. Unique Identifier : AIDSLINE

The human T-lymphotropic retroviruses HTLV-I and HIV-1/-2 share a complementary patchwork homology in which the RRE regions of HIV-1 and -2 cover 78.1% of a 169 nucleotide (nt) region (PX1,2) positioned precisely between open reading frames PX I and PX II of ATLV (HTLV-I). The sequence character of the PX1,2 region is shown to be influenced by a primordial expansion, CTC2T, originating several hundred nucleotides upstream. A second primordial expansion, AGCU(U/C), is identified and shown to represent 52.1% of the HIV-1 RRE region. It is argued that prior to the present AIDS pandemic the efficiency of the rev receptor was enhanced by an ancestral recombination event.

Base Sequence *Evolution Genes, Viral/*GENETICS HIV-1/*GENETICS HIV-2/GENETICS HTLV-BLV Viruses/GENETICS *Models, Genetic Molecular Sequence Data Recombination, Genetic Sequence Homology, Nucleic Acid JOURNAL ARTICLE


Information in this article was accurate in September 30, 1992. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.