Int Conf AIDS. 1992 Jul 19-24;8(3):75 (abstract no. PuB 7157). Unique
OBJECTIVES: Aim of the study was to compare morphological alterations of
peripheral white blood cells from HIV positive and negative male
homosexuals with abnormalities of cellular immunoresponse,
characteristics of sexual behaviour and clinical status. METHODS: Study
population was 35 HIV positive and 19 HIV negative male homosexuals.
Separated peripheral white blood cells/lymphocytes, eosinophils and
polymorphonuclear leukocytes/ were examined electronmicroscopically.
Three categories of morphological alterations were detected: 1.
cytoplasm degenerations/tubuloreticular inclusions/TRI/, nucleus
degenerations/invaginations/and mitochondrial degenerations/myelin-like
structures, giant mitochondrias/. Total number and ratio of CD4 positive
and CD8 positive cells were investigated by immunofluorescent method,
using monoclonal antibodies. Clinical status were set after the criteria
of CDC. RESULTS: Incidence of three sort of cell morphological
abnormalities was significantly higher in the HIV infected group.
Appearance of TRI in lymphocytes and multiple lymphocyte degenerative
alterations showed positive correlation with CDC-stadium. CONCLUSION:
Presence of tubuloreticular inclusions in peripheral blood lymphocytes
from HIV infected homosexuals has a predictive value in clinical
Human HIV Infections/*BLOOD HIV Seropositivity/BLOOD
Lymphocytes/*ULTRASTRUCTURE Male Prognosis ABSTRACT