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Do morphological alterations of peripheral white blood cells have predictive value in progression of HIV-disease?


Int Conf AIDS. 1992 Jul 19-24;8(3):75 (abstract no. PuB 7157). Unique

OBJECTIVES: Aim of the study was to compare morphological alterations of peripheral white blood cells from HIV positive and negative male homosexuals with abnormalities of cellular immunoresponse, characteristics of sexual behaviour and clinical status. METHODS: Study population was 35 HIV positive and 19 HIV negative male homosexuals. Separated peripheral white blood cells/lymphocytes, eosinophils and polymorphonuclear leukocytes/ were examined electronmicroscopically. Three categories of morphological alterations were detected: 1. cytoplasm degenerations/tubuloreticular inclusions/TRI/, nucleus degenerations/invaginations/and mitochondrial degenerations/myelin-like structures, giant mitochondrias/. Total number and ratio of CD4 positive and CD8 positive cells were investigated by immunofluorescent method, using monoclonal antibodies. Clinical status were set after the criteria of CDC. RESULTS: Incidence of three sort of cell morphological abnormalities was significantly higher in the HIV infected group. Appearance of TRI in lymphocytes and multiple lymphocyte degenerative alterations showed positive correlation with CDC-stadium. CONCLUSION: Presence of tubuloreticular inclusions in peripheral blood lymphocytes from HIV infected homosexuals has a predictive value in clinical prognosis.

Human HIV Infections/*BLOOD HIV Seropositivity/BLOOD Lymphocytes/*ULTRASTRUCTURE Male Prognosis ABSTRACT


Information in this article was accurate in December 30, 1992. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.