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Chlamydia pneumoniae seroprevalence in a population of HIV-1 infected children.


Int Conf AIDS. 1992 Jul 19-24;8(3):67 (abstract no. PuB 7111). Unique

OBJECTIVES: HIV-1 infected patients are known to develop frequently respiratory tract infections. Among common pathogens, Chlamydia Pneumoniae (CP) is drawing increasing attention as a respiratory pathogen in adult HIV-1 infected subjects. Yet, to date there are no data regarding HIV-1 pediatric population. METHODS: We enrolled 36 children with vertically transmitted HIV-1 infection and 36 HIV-1 negative controls matched for age (range 5m-9y/3m--median 4y/9m) and sex, who were drawn 6ml of venous blood to perform HIV-1 test (ELISA and WB) and microimmunofluorescence test for IgG and IgM Antibodies specific to CP antigen. For the babies under 15 months of age HIV-1 infection was demonstrated by viral culture and polymerase chain reaction (at least two positive determinations). We used the CDC classification system for HIV-1 infection in pediatric age: all the 36 HIV-1 infected children were clinically symptomatic. RESULTS: CP specific IgG was found in 5 out of 36 (14%) HIV-1 positive and 2 out of 36 (6%) negative children (p = ns). CONCLUSIONS: CP seroprevalence in HIV-1 infected children seems to be slightly higher even though not significantly compared to HIV-1 negative control group. These data deserve further studies on the pathogenetic role of CP in HIV-1 infected children.

Acquired Immunodeficiency Syndrome/COMPLICATIONS/*MICROBIOLOGY Antibodies, Bacterial/*ANALYSIS Child Child, Preschool Chlamydia pneumoniae/IMMUNOLOGY/*ISOLATION & PURIF Chlamydia Infections/COMPLICATIONS Human *HIV-1 IgG/ANALYSIS IgM/ANALYSIS Infant ABSTRACT


Information in this article was accurate in December 30, 1992. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.