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The laboratory criteria of HIV-infection progression.


Int Conf AIDS. 1992 Jul 19-24;8(3):65 (abstract no. PuB 7101). Unique

OBJECTIVES: The detection of immune status indexes characterizing certain HIV-infection stage. METHODS: The immune status dynamic investigation in HIV-infected persons since infection moment till ARC development or AIDS large-scale picture. RESULTS: The immune status dynamic investigation of HIV-infected persons allowed to detect 4 laboratory-immunological stages of HIV-infection. The first one is observed in HIV-infected persons without the disease clinical signs and characterized only by IgA concentration increase in serum; the second is typical for patients with ARC and is manifested by the decrease in CD4+ cells number (to 400-200 cells/mcl), CD16+ cells number decrease and proliferative activity lowering at peripheral blood cells (PBC) stimulation with PWM. At this stage we revealed a stable increase in different Ig classes concentration in serum. The third stage presents AIDS large-scale picture analogues to the second one, except for CD4+ cells which number was reduced to 200. There was the decrease in CD4+ cells number (to 100 and lower), the absence of the effect at PBC stimulation with PWM and normalization or lowering of Ig concentration at the fourth (terminal) stage. CONCLUSIONS: The results obtained demonstrate that not only CD4+ cells are the immune status prognostically significant indexes but Ig concentration and proliferative response to PWM as well. The point of the results discussed is the progressive elimination of CD4+ cells differing by their proliferative activity.

CD4-Positive T-Lymphocytes Human HIV Infections/*IMMUNOLOGY/PATHOLOGY IgG/ANALYSIS Prognosis ABSTRACT


Information in this article was accurate in December 30, 1992. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.