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Lymphoprolipherative disorders in AIDS patients.


Int Conf AIDS. 1992 Jul 19-24;8(3):64 (abstract no. PuB 7090). Unique

OBJECTIVES: To evaluate the incidence, evolution and main epidemiological, clinical and pathological characteristics of lymphoproliferative disorders (LPD) in AIDS patients. METHODS: Retrospective analysis of 480 AIDS patients (85% male) diagnosed and controlled in our Hospital during a period of 81 month (Apr 84-Jan 92). The AIDS risk groups were: IVDU 58%, Homosexual 22%. RESULTS: 39 patients (37 male, mean age: 33 y) developed a LPD. Of them 33 were non-Hodgkin lymphomas (NHL) (20 High grade, 7 Burkitt type; 7 Primary Central Nervous System (CNS); 2 Castleman-like disease), and 6 were Hodgkin diseases (HD). NHL was the AIDS-diagnosing condition in 21 cases (64%). All but one HD occurred in HIV infected patients before the appearance of an AIDS-diagnosing condition. Non-Hodgkin lymphomas: 33 patients (31 males, mean age: 33 y). AIDS risk groups: IVDU 40%, Homosexual 45%. 16 patients (50%) were in clinical stage IV at diagnosis, and extranodal involvement was present in 24 (7 primary CNS). Twenty-eight patients were treated with chemotherapy, of them 4 also received radiotherapy. Twenty-eight (85%) patients died related to LPD. Overall survival period was 5 month (1-31). Hodgkin disease: 6 patients (all males, mean age: 29 y). AIDS risk groups = 66% IVDU, 33% Homosexuals. Five patients were in stage IV with extranodal involvement at diagnosis. All but one patient were treated with chemotherapy. Five patients are alive with a mean survival period of 30 months (2-63). CONCLUSIONS: 1) The incidence of LPD was 8.1% in our series of AIDS patients, with a ratio NHL/HD of 5.5. 2) The LPD was the AIDS-defining condition in 21 cases (64%). 3) Patients with HD had the better prognosis (p less than 0.05), while Primary CNS lymphoma had the poorest. 4) LPD in AIDS patients behaves more aggressively than in non HIV-infected patients, with frequent extranodal involvement, advanced stage at diagnosis and fatal evolution.

Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult Female Human Lymphoproliferative Disorders/*COMPLICATIONS Male Retrospective Studies ABSTRACT


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