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Lymphoprolipherative disorders in AIDS patients.




 

Int Conf AIDS. 1992 Jul 19-24;8(3):64 (abstract no. PuB 7090). Unique

OBJECTIVES: To evaluate the incidence, evolution and main epidemiological, clinical and pathological characteristics of lymphoproliferative disorders (LPD) in AIDS patients. METHODS: Retrospective analysis of 480 AIDS patients (85% male) diagnosed and controlled in our Hospital during a period of 81 month (Apr 84-Jan 92). The AIDS risk groups were: IVDU 58%, Homosexual 22%. RESULTS: 39 patients (37 male, mean age: 33 y) developed a LPD. Of them 33 were non-Hodgkin lymphomas (NHL) (20 High grade, 7 Burkitt type; 7 Primary Central Nervous System (CNS); 2 Castleman-like disease), and 6 were Hodgkin diseases (HD). NHL was the AIDS-diagnosing condition in 21 cases (64%). All but one HD occurred in HIV infected patients before the appearance of an AIDS-diagnosing condition. Non-Hodgkin lymphomas: 33 patients (31 males, mean age: 33 y). AIDS risk groups: IVDU 40%, Homosexual 45%. 16 patients (50%) were in clinical stage IV at diagnosis, and extranodal involvement was present in 24 (7 primary CNS). Twenty-eight patients were treated with chemotherapy, of them 4 also received radiotherapy. Twenty-eight (85%) patients died related to LPD. Overall survival period was 5 month (1-31). Hodgkin disease: 6 patients (all males, mean age: 29 y). AIDS risk groups = 66% IVDU, 33% Homosexuals. Five patients were in stage IV with extranodal involvement at diagnosis. All but one patient were treated with chemotherapy. Five patients are alive with a mean survival period of 30 months (2-63). CONCLUSIONS: 1) The incidence of LPD was 8.1% in our series of AIDS patients, with a ratio NHL/HD of 5.5. 2) The LPD was the AIDS-defining condition in 21 cases (64%). 3) Patients with HD had the better prognosis (p less than 0.05), while Primary CNS lymphoma had the poorest. 4) LPD in AIDS patients behaves more aggressively than in non HIV-infected patients, with frequent extranodal involvement, advanced stage at diagnosis and fatal evolution.

Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult Female Human Lymphoproliferative Disorders/*COMPLICATIONS Male Retrospective Studies ABSTRACT



 




Information in this article was accurate in December 30, 1992. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.