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AZT thymomoduline & lithium carbonate for HIV patients.


Int Conf AIDS. 1992 Jul 19-24;8(3):60 (abstract no. PuB 7067). Unique

OBJECT: AZT has increased the surviving period for AIDS patients, their life-style has improved, and the opportunistic infections are less frequent. However, side-effects are still emerging; leukopenia, (30-50%) it's one of the most important manifestations. We added two other drugs to AZT, both immunomodulating action; Thymomoduline which activates T-Lymphocytes and Lithium Carbonate which stimulates Granulocytic Colony Forming Units. (CM-SCF) to stop myelosuppression. METHODS: Eleven (11p) patients were enrolled in this protocol. All were HIV positive, mean age was 35 years, they were all males. There were 9 (nine) Homosexuals, 1 (one) Hemophilic and 1 (one) Heterosexual. Eight (8) had AIDS, two (2) Demencial Complex, and one (1) L.A.S. All patients suffered a fall in their CD4 count (less than 400/mm3. AZT was given to the patients, with a dose of 500-1200 mg/day, Thymomoduline 20 mg/day and Lithium Carbonate 900 mg/day. RESULTS: Two (2) patients died, all the nine remaining patients are still under treatment, they all have a better life-style, weight gaining, less opportunistic infection episodes, and half of them returned to work. Two (2) patients showed an important fall (decrease) in their white cell (W.C) count (18%). Another patient, who had Leukopenia improved after treatment. Leukocyte count increased (count was above 5000/mm3. Three other are still alive (a 2 year surviving period). Overall, they all improved their CD4 count. COMMENT: Many working groups are trying to combine Antiviral drugs and immunomodulating ones. Leukopenia is a frequent side-effect, when AZT is administer. Thus we consider that treatment should include a combination of Thymomoduline and Lithium Carbonate which have immunostimulating effects, decrease Myelosuppression; this was shown by our working group.

Adjuvants, Immunologic/ADMINISTRATION & DOSAGE Adult Drug Therapy, Combination Human HIV Infections/*DRUG THERAPY/IMMUNOLOGY Lithium Carbonate/*ADMINISTRATION & DOSAGE Male Thymus Extracts/*ADMINISTRATION & DOSAGE Zidovudine/*ADMINISTRATION & DOSAGE ABSTRACT


Information in this article was accurate in December 30, 1992. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.