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The immunosubstitutional treatment with thymus extract and cotrimoxazole of anti-HIV-seropositive addicts.


Int Conf AIDS. 1992 Jul 19-24;8(3):57 (abstract no. PuB 7053). Unique

OBJECTIVE: The aim of this paper is the estimation of eventual influence of immunomodulor drug-Thymusextract/Dr Ollendiek, Germany/and non-specific anti-inflammatory drug-Cotrimoxazole/Biseptol-Polfa/in selected groups of anti-HIV-seropositive addicts. METHODS: First group included 8 anti-HIV-seropositive addicts with persistent generalised lymphadenopathy/PGL/, which received Thymusextract suppositoria 2 times daily a 1500 mg and Cotrimoxazole 2 times daily a 960 mg. Second group/8 patients/along the same classification received only Cotrimoxazole. In laboratory tests after 2 and 4 weeks of observation they were estimated: percentage of lymphocytes T and B, values of CD4 and CD8, circulating immune complexes/CIC/, complement-fractions C3, C4 and immunoglobulins. RESULTS: In the first group it was observed the range of lymphocytes T 61-71, B 20-27, without essential changes after treatment. The values of complement-fractions C3, C4 after treatment were not differentiated The observed primarily high values of IgG were not changed. In the second group the primarily high IgG-values were not essentially changed after treatment. It was observed the decrease of the C3 and C4 values. The values of CD4 were decreased. CONCLUSIONS: Thymusextract and Cotrimoxazole-treatment may influence the disimmunological status of anti-HIV-seropositive addicts with clinical manifested PGL-syndrome.

Drug Therapy, Combination Human HIV Seropositivity/COMPLICATIONS/IMMUNOLOGY/*THERAPY IgG/ANALYSIS Substance Dependence/*COMPLICATIONS T-Lymphocyte Subsets Thymus Extracts/*ADMINISTRATION & DOSAGE Trimethoprim-Sulfamethoxazole Combination/*ADMINISTRATION & DOSAGE ABSTRACT


Information in this article was accurate in December 30, 1992. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.