Int Conf AIDS. 1992 Jul 19-24;8(3):44 (abstract no. PuA 6199). Unique
OBJECTIVE: To determine significant similitudes between HIV-1 proteins
and other known proteins in order to explain some of HIV-1 disorders.
METHODS: We worked on a VAX-VMS system and we used the MIPS data bank
which contains more than 45,000 protein sequences. RESULTS: We have
designed 2 softwares: one is able to screen the whole data bank for
significant homologies with a given sequence; the other one gives an
evaluation on the biological significance of the homologies found. We
applied these softwares on HIV-1 proteins, especially the envelope.
Using these 2 softwares, we have found numerous homologies between HIV-1
and proteins in the MIPS data bank, which were not selected by other
classical screening programs. We also looked for homologies in HIV-2 and
other envelope viruses. The similitudes found concern many proteins
involved in immune T-cell regulation, which gives rise to possible
explanations for HIV-1-induced immune impairment. CONCLUSION:
Implications in the physiopathology of AIDS disease, and for the
development of therapeutic strategies.
Acquired Immunodeficiency Syndrome/PHYSIOPATHOLOGY/THERAPY Amino Acid
Sequence Comparative Study *Databases, Factual Human HIV-1/*GENETICS
Sequence Homology, Nucleic Acid Software Viral Envelope
Proteins/CHEMISTRY/GENETICS Viral Proteins/*CHEMISTRY/GENETICS