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Computer studies on HIV-1 proteins: identification of initial sites.


Int Conf AIDS. 1992 Jul 19-24;8(3):44 (abstract no. PuA 6199). Unique

OBJECTIVE: To determine significant similitudes between HIV-1 proteins and other known proteins in order to explain some of HIV-1 disorders. METHODS: We worked on a VAX-VMS system and we used the MIPS data bank which contains more than 45,000 protein sequences. RESULTS: We have designed 2 softwares: one is able to screen the whole data bank for significant homologies with a given sequence; the other one gives an evaluation on the biological significance of the homologies found. We applied these softwares on HIV-1 proteins, especially the envelope. Using these 2 softwares, we have found numerous homologies between HIV-1 and proteins in the MIPS data bank, which were not selected by other classical screening programs. We also looked for homologies in HIV-2 and other envelope viruses. The similitudes found concern many proteins involved in immune T-cell regulation, which gives rise to possible explanations for HIV-1-induced immune impairment. CONCLUSION: Implications in the physiopathology of AIDS disease, and for the development of therapeutic strategies.

Acquired Immunodeficiency Syndrome/PHYSIOPATHOLOGY/THERAPY Amino Acid Sequence Comparative Study *Databases, Factual Human HIV-1/*GENETICS Sequence Homology, Nucleic Acid Software Viral Envelope Proteins/CHEMISTRY/GENETICS Viral Proteins/*CHEMISTRY/GENETICS ABSTRACT


Information in this article was accurate in December 30, 1992. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.