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Immunogenetic markers in HIV-infected persons.




 

Int Conf AIDS. 1992 Jul 19-24;8(3):41 (abstract no. PuA 6181). Unique

OBJECTIVES: The analysis of AIDS pathogenic mechanisms allow to relate it to the group of multifactoral diseases in the predominance to which the genetic component plays an important role. The genetic blood cells markers were studied in 103 HIV-infected patients detected during examination in Central Hospital (Adis Abeba, Ethyopia). METHODS: The study of HLA systems A, B, C and DR loci antigens was carried out with the help of microlymphocytotoxic test; the ABO, Rh, P, MNSs, Kell-Chelano, Daffy erythrocyte antigens prevalence was defined with the help of corresponding antiserums; The detection frequency of serum markers--haptoglobin (Hp) and transferrin (Tf) was evaluated by means of polyacrylamide gel electrophoresis method. RESULTS: The increase B8 (RR = 7.23) and DR4 (RR = 9.65) of HLA antigens frequency as well as ee (RR = 8.21) erythrocyte Rh-system antigens were detected. Negative associations of HIV-infection were detected with B35 (RR = 0.08) and DQw1 (RR = 0.13) HLA-antigens as well as P+Hp2-2 markers that gives reason to consider them as resistant markers. CONCLUSION: We must conclude that the further deep study of AIDS patients genotype is prospected.

Acquired Immunodeficiency Syndrome/GENETICS/*IMMUNOLOGY Ethiopia Genetic Markers Genotype Human *HIV HIV Infections/GENETICS/*IMMUNOLOGY HLA-A Antigens/*ANALYSIS/GENETICS HLA-B Antigens/*ANALYSIS/GENETICS HLA-C Antigens/*ANALYSIS/GENETICS HLA-DR Antigens/*ANALYSIS/GENETICS ABSTRACT



 




Information in this article was accurate in December 30, 1992. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.