Int Conf AIDS. 1992 Jul 19-24;8(1):Mo10 (abstract no. MoC 0033). Unique
OBJECTIVES: To estimate the risk of developing AIDS for women compared
to that of men, and to identify predictors of clinical progression in
women. METHODS: We conducted a longitudinal study, enrolling individuals
for whom the seroconversion period could be estimated (i.e. availability
of a negative serological test and a subsequent HIV-positive test within
two years of the former date). The seroconversion date was estimated as
the midpoint between the last negative and the first HIV-positive test.
The end-point of the analysis was the AIDS diagnosis. Disease
progression was analyzed according to estimates based on Kaplan-Meier
survival curves. Differences among groups were assessed by the log-rank
test. RESULTS: Two-hundred-thirty-four females (141 IDUS; 93
heterosexual contact) and 422 males (377 IDUS; 45 heterosexual contact)
from 16 Italian clinical facilities were enrolled in the study. The mean
age was 25.93 years (24.59 for females and 26.67 for males). The median
seroconversion interval (the period between the last negative and first
positive test) was 7.95 months (8.02 for females and 7.06 for males).
The median follow-up time was 43.97 months (38.23 females; 45.23 males).
Seven women and 31 men developed AIDS during the study period. The
estimated cumulative incidence of AIDS was 3.49% (95% C.I. 0.24-6.74)
for women and 6.08% (95% C.I. 3.30-8.86) for men within 4 years after
seroconversion. No significant differences were found in the progression
of HIV between women and men. Women over 25 years old at seroconversion
were more likely to develop AIDS than those younger than 25. No
differences were found in women between injecting drug users and
heterosexual contacts. CONCLUSIONS: In industrialized countries, the
natural history of HIV infection in women does not seem to differ from
that of men. Factors such as older age at seroconversion may play a role
in accelerating the progression from HIV infection to AIDS.
Acquired Immunodeficiency Syndrome/*EPIDEMIOLOGY Adult Age Factors
Comparative Study Female Human HIV
Prospective Studies Sex Behavior Substance Abuse,