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NLM AIDSLINE

[Toxoplasmosis in AIDS]




 

Presse Med. 1992 Jul 4-11;21(25):1165-71. Unique Identifier : AIDSLINE

Toxoplasmosis is one of the major opportunistic infections observed in France in 15 to 37 percent of HIV-infected patients. Its main manifestation is encephalitis. Other, less frequent manifestations are chorioretinitis, pneumonia or disseminated toxoplasmosis. The conventional treatment is a combination of pyrimethamine 50-75 mg/day and sulfadiazine 6-8 g/day. Acute therapy should be pursued for at least 3 weeks or until optimal response is achieved, i.e. 6 to 8 weeks in most cases. The pyrimethamine-clindamycin combination in doses of at least 2.4 g/day is a possible alternative. Other drugs are being studied, but there is still a need for new drugs active against the parasite, that could be used in humans. In HIV-infected patients treatment should be maintained lifelong to prevent relapses. Maintenance regimens use the same drugs as acute therapy but in lower doses. The main field of research is primary prophylaxis of toxoplasmosis in HIV-infected patients.

Acquired Immunodeficiency Syndrome/*COMPLICATIONS Antibiotics/THERAPEUTIC USE AIDS-Related Opportunistic Infections/DIAGNOSIS/ETIOLOGY/THERAPY Clindamycin/ADMINISTRATION & DOSAGE/THERAPEUTIC USE English Abstract Human Lung Diseases, Parasitic/COMPLICATIONS/DIAGNOSIS/THERAPY Pyrimethamine/ADMINISTRATION & DOSAGE/THERAPEUTIC USE Recurrence Sulfadiazine/ADMINISTRATION & DOSAGE/THERAPEUTIC USE Toxoplasmosis/DIAGNOSIS/*ETIOLOGY/THERAPY Toxoplasmosis, Cerebral/DIAGNOSIS/ETIOLOGY/THERAPY Toxoplasmosis, Ocular/DIAGNOSIS/ETIOLOGY/THERAPY JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL



 




Information in this article was accurate in January 30, 1993. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.