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Feline immunodeficiency virus neurotropism: evidence that astrocytes and microglia are the primary target cells.


Vet Immunol Immunopathol. 1992 Dec;35(1-2):23-35. Unique Identifier :

To investigate the neuropathogenesis of feline immunodeficiency virus (FIV) infection in vitro, we have utilized three populations of cultured feline neural cells (astrocytes, microglia, brain endothelium) to assess the relative susceptibility to FIV infection, ability to produce viral antigens, and effects of infection on cell survival. Astrocytes appeared to be the most susceptible to infection, followed by microglia, whereas brain endothelial cells were relatively resistant to infection. Astrocyte infection resulted in syncytium formation and cell death, while microglial cells remained persistently and productively infected, without obvious cytopathic effects. These results suggest that FIV entry into the central nervous system probably does not occur via infected endothelium and that both astrocytes and microglia are more likely target cells for the virus.

Animal Antigens, Viral/ANALYSIS Astrocytes/CYTOLOGY/*MICROBIOLOGY Cats Cell Survival Cells, Cultured Cerebral Cortex/*BLOOD SUPPLY/MICROBIOLOGY Endothelium, Vascular/CYTOLOGY/*MICROBIOLOGY Fluorescent Antibody Technique Gene Products, gag/ANALYSIS Immunodeficiency Virus, Feline/IMMUNOLOGY/ISOLATION & PURIF/ *PHYSIOLOGY Neuroglia/CYTOLOGY/*MICROBIOLOGY Specific Pathogen-Free Organisms Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE


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