pathologic features and immunofluorescent antibody demonstration of ocular microsporidiosis (encephalitozoon hellem) in seven patients with acquired immunodeficiency syndrome [see comments]

NLM AIDSLINE Pathologic features and immunofluorescent antibody demonstration of ocular microsporidiosis (Encephalitozoon hellem) in seven patients with acquired immunodeficiency syndrome [see comments] Schwartz DA; Visvesvara GS; Diesenhouse MC; Weber R; Font RL; Wilson LA;
June 30, 1993

Am J Ophthalmol. 1993 Mar 15;115(3):285-92. Unique Identifier : AIDSLINE We studied the clinicopathologic features of seven patients with acquired immunodeficiency syndrome (AIDS) and ocular microsporidiosis. All patients had decreased levels of CD4-positive cells (mean, 26/ml3) and ocular symptoms; five had bilateral punctate epithelial keratopathy, one had intermittent red eyes with conjunctivitis, and one had red eyes only. Light and electron microscopy of corneal and conjunctival biopsy and cytologic specimens and intact globes disclosed microsporidia belonging to the genus Encephalitozoon. Because E. cuniculi and E. hellem, the two species of the Encephalitozoon genus, are morphologically identical, an immunofluorescent antibody technique was used for species identification. In all seven patients, the agent was identified as E. hellem. Pathologic examination of globes obtained after autopsy disclosed E. hellem infection to be restricted to the corneal and conjunctival epithelium. We studied methods for the routine diagnosis of ocular microsporidiosis in patients with AIDS, including the role of immunofluorescent antibody staining. Adult Animal Antibodies, Protozoan/ANALYSIS AIDS-Related Opportunistic Infections Conjunctival Diseases/IMMUNOLOGY/PATHOLOGY/PARASITOLOGY Corneal Diseases/IMMUNOLOGY/PATHOLOGY/PARASITOLOGY CD4-Positive T-Lymphocytes Encephalitozoon/IMMUNOLOGY/ULTRASTRUCTURE Encephalitozoonosis/IMMUNOLOGY/PATHOLOGY Eye Infections, Parasitic/IMMUNOLOGY/PATHOLOGY Female Fluorescent Antibody Technique Human Male Middle Age JOURNAL ARTICLE

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Information in this article was accurate in June 30, 1993. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.