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Replicative viral DNA in Epstein-Barr virus associated Burkitt's lymphoma biopsies.


Leuk Res. 1993 Mar;17(3):285-9. Unique Identifier : AIDSLINE

Epstein-Barr virus (EBV) is linked to a spectrum of human diseases including epithelial and lymphoid malignancies in which it exists predominantly in a latent state. EBV is capable of establishing replicative infection at oropharyngeal and genital sites. Replicative EBV infection also occurs in oral hairy leukoplakia, in EBV associated lymphoproliferative disorders, and to a minor degree in nasopharyngeal carcinomas. Recent evidence also suggests that EBV replication, also, may be associated with AIDS related lymphomas and Hodgkin's disease. However it is widely believed that virus in circulating B-lymphocytes and in B-cell malignancies is stringently latent. We now show that by Southern blot analysis we can detect replicative forms of virion DNA in 14.5% (8 of 55) of EBV-positive Burkitt's lymphoma biopsies. This may be the explanation for the elevation of the titres of lytic cycle EBV antigens that is associated with presentation and relapse of EBV associated Burkitt's lymphoma.

Biopsy Burkitt's Lymphoma/*MICROBIOLOGY/PATHOLOGY DNA Replication/*PHYSIOLOGY DNA, Viral/GENETICS/*PHYSIOLOGY Genome, Viral Herpesvirus 4, Human/GENETICS/*PHYSIOLOGY Human Lymphoma, AIDS-Related/MICROBIOLOGY Plasmids/GENETICS Support, Non-U.S. Gov't Virus Replication/*PHYSIOLOGY JOURNAL ARTICLE


Information in this article was accurate in June 30, 1993. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.