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Retrovirus-like particles in an Epstein-Barr virus-producing cell line derived from a patient with chronic progressive myelopathy.


Acta Neurol Scand. 1993 Feb;87(2):71-6. Unique Identifier : AIDSLINE

A B-lymphoblastoid cell line (LCL) of polyclonal origin was isolated from a 30-year-old male patient with a chronic progressive myelopathy clinically resembling multiple sclerosis (MS). The LCL expresses Epstein-Barr virus (EBV) encoded proteins and on transmission electron microscopy (EM) the LCL was shown to produce both EBV particles and retrovirus-like particles spontaneously. The LCL was negative for human retrovirus (HIV-I and HTLV-I) sequences by polymerase chain reaction (PCR). Furthermore the patient was seronegative to these retroviruses including HTLV-II and HIV-II. We, therefore, suggest that the LCL is double-infected with EBV and a hitherto uncharacterized human retrovirus. The possible implications of these two viruses on development of diseases are discussed.

Adult Antigens, CD/ANALYSIS Cell Line, Transformed/MICROBIOLOGY/PATHOLOGY Diagnosis, Differential Fluorescent Antibody Technique Herpesvirus 4, Human/*ULTRASTRUCTURE Human HIV-1/ULTRASTRUCTURE HTLV-I/ULTRASTRUCTURE Inclusion Bodies, Viral/*ULTRASTRUCTURE Male Microscopy, Electron Multiple Sclerosis/*MICROBIOLOGY/PATHOLOGY Paraparesis, Tropical Spastic/*MICROBIOLOGY/PATHOLOGY Polymerase Chain Reaction Retroviridae/*ULTRASTRUCTURE Support, Non-U.S. Gov't JOURNAL ARTICLE


Information in this article was accurate in June 30, 1993. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.