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HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease [see comments]


Nature. 1993 Mar 25;362(6418):355-8. Unique Identifier : AIDSLINE

Primary infection with the human immunodeficiency virus (HIV) is generally followed by a burst of viraemia with or without clinical symptoms. This in turn is followed by a prolonged period of clinical latency. During this period there is little, if any, detectable viraemia, the numbers of infected cells in the blood are very low, and it is extremely difficult to demonstrate virus expression in these cells. We have analysed viral burden and levels of virus replication simultaneously in the blood and lymphoid organs of the same individuals at various stages of HIV disease. Here we report that in early-stage disease there is a dichotomy between the levels of viral burden and virus replication in peripheral blood versus lymphoid organs. HIV disease is active in the lymphoid tissue throughout the period of clinical latency, even at times when minimal viral activity is demonstrated in blood.

Acquired Immunodeficiency Syndrome/MICROBIOLOGY Adenoids/MICROBIOLOGY Adult Blood/MICROBIOLOGY Child, Preschool Dendritic Cells/ULTRASTRUCTURE DNA, Viral Female Human HIV Infections/*MICROBIOLOGY HIV Seropositivity/MICROBIOLOGY HIV-1/*GROWTH & DEVELOPMENT/GENETICS In Situ Hybridization Inclusion Bodies, Viral/ULTRASTRUCTURE Lymph Nodes/MICROBIOLOGY/PATHOLOGY Lymphocytes/MICROBIOLOGY Lymphoid Tissue/*MICROBIOLOGY Male Microscopy, Electron Polymerase Chain Reaction Support, Non-U.S. Gov't Tonsil/MICROBIOLOGY JOURNAL ARTICLE


Information in this article was accurate in June 30, 1993. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.