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The role of fluoroquinolones in sexually transmitted diseases.




 

Pharmacotherapy. 1993 May-Jun;13(3):189-201. Unique Identifier :

The management of sexually transmitted diseases (STDs) has reached a new level in the era of antibiotic resistance and human immunodeficiency virus infection. To date, no single antimicrobial is capable of eradicating the commonly encountered STD pathogens including Neisseria gonorrhoeae, Chlamydia trachomatis, and Treponema pallidum. Among the marketed fluoroquinolones, ciprofloxacin, ofloxacin, lomefloxacin, and enoxacin all provide excellent in vitro activity (MIC90 < 0.06 micrograms/ml) and excellent in vivo efficacy against N. gonorrhoeae, including multiply resistant isolates (penicillinase-producing N. gonorrhoeae and chromosomally mediated resistant N. gonorrhoeae). Ofloxacin is the only fluoroquinolone approved by the Food and Drug Administration for chlamydial infection. All of the quinolones lack reliable in vitro activity against Ureaplasma urealyticum, a cause of nongonococcal urethritis. Although limited data suggest the usefulness of ciprofloxacin and ofloxacin in the treatment of pelvic inflammatory disease, these drugs cannot currently be recommended for single-agent therapy. Haemophilus ducreyi infections, however, can be managed effectively with the fluoroquinolones. Although their role continues to evolve, this class of drugs cannot be used equally to treat all STDs, and notably, no quinolone to date inhibits T. pallidum.

Adnexitis/DRUG THERAPY Anti-Infective Agents, Fluoroquinolone/*THERAPEUTIC USE Chancroid/DRUG THERAPY Chlamydia trachomatis Chlamydia Infections/DRUG THERAPY Comparative Study Female Gonorrhea/DRUG THERAPY Human Male Microbial Sensitivity Tests Mycoplasma Infections/DRUG THERAPY Sexually Transmitted Diseases, Bacterial/*DRUG THERAPY Syphilis/DRUG THERAPY Ureaplasma urealyticum Ureaplasma Infections/DRUG THERAPY JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL



 




Information in this article was accurate in October 30, 1993. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.