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HIV-1 envelope gp120 alters astrocytes in human brain cultures.


AIDS Res Hum Retroviruses. 1993 May;9(5):439-44. Unique Identifier :

The majority of AIDS patients will experience some degree of dementia induced by human immunodeficiency virus (HIV-1). In this study, we report that treatment of human brain tissue with envelope gp120 of HIV-1 did not cause neuronal death but did cause astrocyte alterations and/or death. Human astrocyte cultures showed decreased expression of glial fibrillary acidic protein (GFAP), as well as the diminution of a major protein of 66 kDa. These findings are similar to the in vitro changes observed when astrocytes are exposed to ammonia and in vivo changes observed in experimental hepatic encephalopathy. We hypothesize that AIDS dementia may partially involve a perturbation of astrocyte function by gp120 that could indirectly impair neuronal function.

Astrocytes/*DRUG EFFECTS/METABOLISM/PATHOLOGY AIDS Dementia Complex/ETIOLOGY Binding Sites Brain/DRUG EFFECTS/METABOLISM/PATHOLOGY Cell Aggregation/DRUG EFFECTS Cell Death/DRUG EFFECTS Cells, Cultured Human HIV Envelope Protein gp120/METABOLISM/*TOXICITY HIV-1/*PATHOGENICITY Macrophages/DRUG EFFECTS Microscopy, Electron Nerve Tissue Proteins/METABOLISM Neurons/DRUG EFFECTS Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. JOURNAL ARTICLE


Information in this article was accurate in October 30, 1993. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.