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Phylogenetic and geographical analysis of HTLV-1/STLV-1 in the world.


Int Conf AIDS. 1993 Jun 6-11;9(1):269 (abstract no. PO-A34-0810). Unique

OBJECTIVE: Some new isolates including those from Gabon, Ghana, India and AINU people in Japan were genomically analysed and compared phylogenetically with other HTLV-1/STLV-1 reported previously. METHODS: Phylogenetic tree was constructed by use of nucleotide sequences of the part of LTR. RESULTS: There are 5 groups of HTLV-1 (A, B, C, D and E) in human. Group A consists of Caribbean, Indian and Japanese isolates including that from AINU people, and group B consists of almost Japanese isolates except for one Indian isolate, suggesting that there are two ancestral lineages of the Japanese HTLV-1 and one of them (group A) was brought to Caribbean basin. Group C consists of the West African and Caribbean isolates, indicating that the part, not all, of Caribbean strain directly originated from West Africa. Group D consists of the isolates from central region of Africa and made one cluster together with STLV-1 from chimpanzee, suggesting the interspecies transmission between human and non-human primate in the past. Group E consists of melanesian isolates which diverged at the earlist among the groups. There is no specific clustering linked to the pathogenicity, such as ATL and HAM/TSP. CONCLUSION: The topology of the phylogenetic tree of this virus may reflect the movement of the people who had the virus in the past.



Information in this article was accurate in November 30, 1993. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.