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Transitory elevation of treponemal immunoglobulins in HIV-patients successfully treated for neurosyphilis.


Int Conf AIDS. 1993 Jun 6-11;9(1):390 (abstract no. PO-B11-1531). Unique

OBJECTIVE: In a prospective study we evaluated longitudinal changes in serum- and CSF-antibody production against treponema pallidum following high dose antibiotic treatment in HIV seropositive homosexuals (HIVs) with neurosyphilis. METHODS: Nine HIVs were treated with high dose Penicillin for active neurosyphilis. Serologic tests in serum and CSF (VDRL, FTA-ABS-IgG, 19-S-IgM-FTA-ABS) were performed before and after antibiotic treatment. The data were correlated to clinical response and concurrent changes of CSF parameters (Cell count, protein, IgG-index and oligoclonal bands). RESULTS: Penicillin therapy induced transitory elevation of the VDRL in 4 of 9 patients. In another patient the CSF FTA-ABS-IgG became positive. All 5 patients improved clinically and pretreatment CSF pleocytosis (4 of 5) decreased (one normal CSF cell count remained unchanged). CONCLUSION: Transitory enhancement of treponemal antibody production can result from antibiotic therapy and may not represent treatment failure.

*Antibodies, Bacterial/BLOOD *HIV Infections/COMPLICATIONS *HIV Seropositivity/COMPLICATIONS *IgG/BLOOD *IgM/BLOOD *Neurosyphilis/DRUG THERAPY *Neurosyphilis/IMMUNOLOGY *Penicillins/THERAPEUTIC USE


Information in this article was accurate in November 30, 1993. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.