patterns predictive of outcome for episodes of pcp, 1983-90, using factor analysis.

NLM AIDSLINE Patterns predictive of outcome for episodes of PCP, 1983-90, using factor analysis. Peters BS; Beck EJ; Kupek E; Coleman DG; Weber J; Mitchell D; St. Mary's
November 30, 1993

Int Conf AIDS. 1993 Jun 6-11;9(1):375 (abstract no. PO-B10-1438). Unique AIM: Describe the outcome of first time and index episodes of PCP at St. Mary's Hospital, London, 1983-1990 in terms of use of health services, case-severity, immunosuppression, treatment, longterm survival. METHODS: Case-notes analysed retrospectively. Factor analysis of variables associated with a fatal vs. non-fatal episode of PCP RESULTS: All episodes-2 patterns are predictive non-fatal outcome: (1) Predominantly since 1987 early presentation, few coinfections, low case-severity, low immunosuppression, related therapy, longterm survival (2) Constant over time low use health services, above average case-severity, low immunosuppression, moderate longterm survival. One pattern predictive of fatal outcome: predominantly before 1987, late presentation, high case-severity, high immunosuppression. Index episodes: -2 patterns predictive non-fatal outcome both predominantly since 1987: (1) early presentation, high service use, low case-severity, low immunosuppression, related therapy, longterm survival. (2): early presentation, high service use, low case-severity, low immunosuppression, related treatment, moderate longterm survival. 2 fatal patterns occurred: (1) predominantly before 1987 late presentation, high case-severity, high immunosuppression, related treatment. (2) predominantly since 1987 above average case-severity, below average immunosuppression, treatment with corticosteroids. CONCLUSIONS: (1) Different patterns of severity treatment predict outcome from episode of PCP; some patterns vary over time (2) Findings emphasise the importance of health care utilization as well as specific therapies in determining outcome. AIDS-Related Opportunistic Infections/THERAPY Pneumonia, Pneumocystis carinii/THERAPY

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