neuroimmunological studies in murine models of meningoencephalitis by opportunistic fungi.

NLM AIDSLINE Neuroimmunological studies in murine models of meningoencephalitis by opportunistic fungi. Blasi E; Mazzolla R; Barluzzi R; Puliti M; Bistoni F; Department of
November 30, 1993

Int Conf AIDS. 1993 Jun 6-11;9(1):371 (abstract no. PO-B09-1416). Unique To investigate the immune defense mechanisms employed against fungi at cerebral level, experimental infection of mice was performed by intracerebral (i.c.) inoculation of Candida albicans or Cryptococcus neoformans in naive and immunomodulated mice. While no mice survived either C. albicans or C. neoformans challenge at doses > or = 10(6) yeasts/mouse, major differences were observed, by lowering the inoculum size (< or = 10(5) yeasts/mouse): C. albicans was no longer lethal (100% survival), whereas 100 and 70% of the mice still succumbed to 10(4) and 10(3) C. neoformans challenging doses. Pharmacological manipulation and transfer experiments revealed that the myelomonocytic compartment had a minor role against C. neoformans, while it was deeply involved in the control of C. albicans i.c. infection. By quantitative evaluation of yeasts in the brain of naive and immunomodulated animals, we established that, unlike C. albicans, C. neoformans remained essentially in the brain where massive organ colonization/damage occurred, regardless of the fact that naive or immunomodulated defense mechanisms were employed by the host. Overall, these data suggest that the differential role exerted by the myelomonocytic compartment, together with the diverse tropism of the two fungi, can explain the different development and outcome of C. albicans and C. neoformans i.c. infections. Candidiasis/IMMUNOLOGY Cryptococcosis/IMMUNOLOGY Encephalitis/IMMUNOLOGY Meningitis/IMMUNOLOGY Meningitis, Cryptococcal/IMMUNOLOGY Opportunistic Infections/IMMUNOLOGY

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