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Itraconazole solution in patients with non-response to fluconazole.


Int Conf AIDS. 1993 Jun 6-11;9(1):368 (abstract no. PO-B09-1394). Unique

OBJECTIVE: Clinical response of treatment with itraconazole solution in AIDS patients with oral candidiasis who failed to fluconazole treatment. Initial successful therapy with itraconazole was followed by long-term suppressive treatment. METHODS: Between 06/90 and 01/93 30 AIDS patients with clinical non-response to high-dose fluconazole therapy were treated with itraconazole in an open study with control of itraconazole serum levels. RESULTS: 28 of 30 patients were given 200-400mg itraconazole/d, 2 of 30 patients 600-800 mg Itraconazol/d. Duration of treatment was 12-237 days (mean 66 days). 25 of 30 patients had clinical response, 5 of 30 patients had initial response and relapse before death. Serum levels of itraconazole had individual variability and poor correlation to clinical response. CONCLUSION: Itraconazole solution is an effective therapy in patients non response to fluconazole.

*Antifungal Agents/THERAPEUTIC USE *AIDS-Related Opportunistic Infections/DRUG THERAPY *Candidiasis, Oral/DRUG THERAPY *Ketoconazole/ANALOGS & DERIVATIVES


Information in this article was accurate in November 30, 1993. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.