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Particularities of TB in HIV infected children/AIDS in Constanta-Romania.


Int Conf AIDS. 1993 Jun 6-11;9(1):321 (abstract no. PO-B07-1117). Unique

OBJECTIVES: Study of pulmonary and extrapulmonary TB in 700 children hospitalized for HIV infection/AIDS in Municipal Hospital of Constanta from July '82 until December '82. METHODS: Clinical, laboratory and X-ray study of 70 cases of TB in HIV infected children, evolution and treatment. RESULTS: TB was diagnosed in 10% of HIV infected cases at children with age between 3 months and 6 years, 38 boys (55%) and 32 girls (45%). We diagnosed 51 cases of pulmonary tuberculosis (72%), 17 pulmonary and extrapulmonary tuberculosis (24%) and only 2 extrapulmonary tuberculosis (4%). Clinical characteristics: pneumopathy, extrathoracic tuberculous lymphadenopathy, abscesses, pericarditis, meningitis, osteo-arthritis. These were accompanied always by fever, weight loss, cough. Intradermal skin testing with PPD was negative (positive just in one case). Bacteriological diagnoses was realized on Ziehl-Neelsen staining to be packed with acid-fast bacilli (from CSF, pericardial fluid, peritoneal fluid, bronchoalveolar-lavage fluid), or (much more rare) by culture in 20 cases (20%). The histologic diagnosis was always pathognomonic when it was realized at autopsy or after lymph node biopsy or liver biopsy. Chest roentgenographic findings were diffuse lesions (interstitial or micronodular), upper-lobe infiltrate, pleural effusions, pericarditis; cavitations were not relevant. 15 children died. Treatment with isoniazid 10 mg/bw daily, rifampin 15 mg/bw daily and pyrazinamide 25 mg/bw daily. DISCUSSION: Many cases of atypical TB; many cases with multiple places of tuberculous infections pulmonary, lymph node meningitis, skin abscess, pericardial, peritoneal).



Information in this article was accurate in November 30, 1993. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.