Int Conf AIDS. 1993 Jun 6-11;9(1):319 (abstract no. PO-B06-1101). Unique
OBJECTIVE. The possibility that HIV infection could worsen or reactivate
Q fever is likely. We performed sero-survey in order to evaluate the
importance of exposure to Coxiella burnetti of HIV-infected people
living in Paris, France, and in Bangui, Central African Republic, two
different areas for both HIV and C. burnetti prevalences. METHOD. Blood
samples were collected from 109 African subjects (65 HIV-1+, 44 HIV-
healthy controls) living in Bangui, from 885 healthy HIV- blood donors,
and 910 HIV-1+ subjects seen in Broussais hospital, Paris, irrespective
of their clinical or immunological status. Serum IgG antibody to C.
burnetti (phase II) titers were determined by indirect immunofluorescent
assay (cut-off value for positivity, > or = 1:200). A pooling strategy
was used for the French sera. RESULTS. TABULAR DATA, SEE ABSTRACT
VOLUME. CONCLUSIONS. (i) There is no obvious link between HIV and C.
burnetti infections. (ii) High number of HIV-positive individuals have
serologic evidence for C. burnetti infection. (iii) Host defenses in Q
fever (principally cell-mediated immunity) are strikingly associated
with the severity of the disease, and physicians should be aware to
possible symptomatic C. burnetti infection among HIV-infected people.
*HIV Infections/EPIDEMIOLOGY *Q Fever/EPIDEMIOLOGY