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Increase of HIV-2 and HIV-1 infection in tuberculosis (TB) cases in Guinea Bissau.


Int Conf AIDS. 1993 Jun 6-11;9(1):316 (abstract no. PO-B06-1087). Unique

OBJECTIVE: To evaluate if an increase of TB correlated to HIV-2 infection occurs, and if there is an appearance of HIV-1 infection among TB patients in a Country where the prevalent serotype is HIV-2. METHODS: From August '91 to July '92 we studied 630 TB patients, 366 males average age 42 y. (R 87.2) and 264 females average age 40 y (R 75-1) with evaluation of HIV-2 and HIV-1 (ELISA and Western blot). RESULTS: In the last 5 months of '91, 50 of the 260 pt. (19.23%) were HIV-2 positive, 2 (0.76%) were HIV-1 positive, and 1 showed also by W.B. double reactivity. In the first 7 months of '92, 81 (21.9%) of the 370 studied were HIV-2 positive, 9 (2.43%) were HIV-1 positive and 7 (1.89%) showed double reactivity by W.B. The overall HIV-2 and HIV-1 seroprevalence was 26%. CONCLUSIONS: The studies we made in 1990 showed in TB patients and HIV-2 seroprevalence of 17.73% while in 1989 it was of 14.8%. The epidemiological data which we possess show a substantial stability in Guinea Bissau of new TB cases registered in 1990 (1153) and 1991 (1105) (unpublished), while there is an increase in seroprevalence for HIV-2 and recently for HIV-1. Further longitudinal studies on this patient's population are needed to determine the specific role of HIV-2 and HIV-1 in TB spreading and evolution.

*AIDS-Related Opportunistic Infections/EPIDEMIOLOGY *HIV Infections/EPIDEMIOLOGY *HIV-1 *HIV-2 *Tuberculosis, Pulmonary/EPIDEMIOLOGY


Information in this article was accurate in November 30, 1993. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.