human b and t cell response to the hla like epitopes of the hiv-1 gp120 c5 region.

NLM AIDSLINE Human B and T cell response to the HLA like epitopes of the HIV-1 gp120 C5 region. Beretta A; Rappocciolo G; Lopalco L; DeSantis C; Longhi R; Siccardi AG;
November 30, 1993

Int Conf AIDS. 1993 Jun 6-11;9(1):29 (abstract no. WS-A13-1). Unique We have investigated the human antibody and T cell response to the C5 region of HIV-1 gp120. Synthetic peptides containing two amino acid regions previously identified as antigenically homologous to the a-1 domain of HLA C antigens were used to absorb HLA cross-reactive serum antibodies from HIV infected individuals and to stimulate peripheral lymphocytes from normal HIV negative individuals. Results obtained with immunoaffinity purified antibody fractions indicated that the totality of the antibody response to the C5 region, including specific antibodies to the previously described immunodominant C terminus peptide, are cross-reactive to HLA class I C heavy chains which are expressed only at the surface of activated cells. No antibodies to a sequence of nine aa (IEPLGVAPT) containing potentially neutralizable residues could be detected. Peripheral T cells from normal HIV negative donors showed proliferative responses to the HLA like gp120 peptides in primary cultures showing, as expected on the basis of the immune reactivity to MHC antigens, a high frequency of precursor T cells to this gp120 region. T cell lines and clones generated against the gp120 peptides could recognize specifically both the gp120 and the HLA peptides showing that the antigenic mimicry of the two regions plays a role both at the B cell and T cell level. B-Lymphocytes/IMMUNOLOGY Epitopes/IMMUNOLOGY Histocompatibility Antigens Class I/IMMUNOLOGY HIV Envelope Protein gp120/IMMUNOLOGY *T-Lymphocytes/IMMUNOLOGY

Most Read: Latest Added Related Topics White House LGBT Conference on HIV/AIDS UNITED STATES: White House in Atlanta: LGBT AIDS Conference No more single-theme conferences: global HIV prevention conference planned FHI 360 Senior Scientist Lut Van Damme Receives International Microbicide Conference Lifetime Achievement Award Equatorial Guinea Ministry of Health and Social Welfare and UNICEF Refute Erroneous AIDS Prevalence Figures Photographs from A Day with HIV Now Online Bulgaria urges Libya to investigate AIDS nurses case Engineers enter fight against AIDS in Africa Gilead’s Complera® Non-Inferior to Atripla® Among Treatment-Naive HIV Patients UN chief Ban calls world leaders to end Aids by 2020 OHIO: Phila Health Department HIV Testing Well-Received CONNECTICUT: City's Circle Care Center is a Model for HIV Prevention UNITED STATES: New Compound Excels at Killing Persistent and Drug-Resistant Tuberculosis INDIA: India Faces TB Drug Shortage, Warns International Medical Org ALASKA: After Topping List for Chlamydia Rates, Alaska Seeing Some Improvement Tanzania: Police Abuse, Torture, Impede HIV Services Growing HIV/AIDS awareness in Indonesia's Papua region South Africa: Catastrophe as Eastern Cape drug stock-outs continue Community-led programmes critical to progress on AIDS in Sri Lanka One in Four Surveyed EU5 Physicians Has Been Required to Change a Prescription for Some or Most of Their HIV Patients in the Past Twelve Months, Primarily to Reduce Costs OHIO: Phila Health Department HIV Testing Well-Received CONNECTICUT: City's Circle Care Center is a Model for HIV Prevention TAIWAN: HIV/AIDS Spreading to Younger People in Taiwan FLORIDA: Groups Offering Free HIV Testing INDIA: HIV Prevention Among Female Sex Workers in India Reduces HIV and Syphilis Tanzania: Police Abuse, Torture, Impede HIV Services Growing HIV/AIDS awareness in Indonesia's Papua region US program marks birth of one millionth HIV-free baby One in Four Surveyed EU5 Physicians Has Been Required to Change a Prescription for Some or Most of Their HIV Patients in the Past Twelve Months, Primarily to Reduce Costs How long can one born with HIV live?
Information in this article was accurate in November 30, 1993. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.