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NLM AIDSLINE

Evolution of plasmatic and cellular viral load in a symptomatic primary HIV infection.




 

Int Conf AIDS. 1993 Jun 6-11;9(1):285 (abstract no. PO-B01-0902). Unique

OBJECTIVES: To quantify the plasmatic and cellular viral loads in symptomatic primary HIV infection. METHODS: HIV serology, serum p24 antigen (p24 ag) monoclonal and polyclonal assay in pg/ml Abbott) (and after immune complex dissociation (ICD) for monoclonal assay), cellular (TCID 50/10(6) cells) and plasmatic TCID 50/ml) viremias, plasma HIV-RNA (PCR) were measured at 1st, 4th and 8th days of a symptomatic primary HIV infection. TABULAR DATA, SEE ABSTRACT VOLUME. RESULTS AND CONCLUSIONS: The highest plasma and cellular viral titers were found at least twice-fold more increased than the values observed in CDC IV patients; viremia, plasma HIV-RNA and serum p24 ag rapidly declined over time, while cellular viremia increased. The values reached by both plasma and cellular loads suggest an increased possibility of viral dissemination in organism, which could constitute an argument to use therapy specifically decreasing the viral load at this stage of infection.

*HIV/ISOLATION & PURIF *HIV Infections/MICROBIOLOGY *Viremia/MICROBIOLOGY



 




Information in this article was accurate in November 30, 1993. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.