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Clinical and immunological impact of routine vaccination in HIV infected children.


Int Conf AIDS. 1993 Jun 6-11;9(1):285 (abstract no. PO-B01-0903). Unique

OBJECTIVE: To evaluate the impact of routine vaccination in P-1 and P-2 HIV infected children followed prospectively. METHODS: 21 children were studied in 62 episodes of vaccination. CD4, CD8 and p24 antigenemia were monitored at day of injection and post vaccine at 15-30 days in 40 episodes; 30-60 days in 8 episodes, 60-90 days in 8 episodes and over 90 days in 6 episodes. Evaluation of clinical status was done at time of vaccination, 2, 4 and 6 months after vaccination; a change in CDC classification, a new AIDS defining illness or hospitalization was considered a significant clinical event. RESULTS: Children received a mean of 7.7 injections in 62 episodes (42 DPT, 41 IPV, 1 OPV, 12 MMR, 7 prohibit, 6 engerix). No major adverse reactions were noted. A change in clinical status was noted 2 months post injection in 13/62 episodes, especially in the very young (mean 4.4 months) and male (12/13) infants. A 25% drop in CD4 count in 54% of episodes, a 50% drop in 20% of episodes and an increase of more than 300U/ml of p24 antigen was noted in 11/62 episodes. CONCLUSION: These changes are impressive but because of the limited number of patients studied and the time frame when these changes occur, data does not reach a statistically significant level; those findings could reflect the natural history of HIV in children.



Information in this article was accurate in November 30, 1993. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.