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CD4+ T lymphocytes negatively regulate interleukin-1 (IL-1) activity by inducing the secretion of IL-1 receptor antagonist IL-1 RA) by monocytes from HIV-infected individuals.




 

Int Conf AIDS. 1993 Jun 6-11;9(1):175 (abstract no. PO-A13-0245). Unique

We have previously shown that peripheral blood monocytes from HIV-infected patients constitutively produce IL-1 alpha and beta AIDS, 1989, 3, 695). In the present study, we observed that monocytes from HIV+ donors cultured in the presence of autologous T lymphocytes release less IL-1 activity (as assessed by a comitogenic assay) than purified monocytes cultured in the absence of T cells, without affecting the amount of released IL-1 protein. Inhibition of release of IL-1 activity was also observed when autologous T lymphocytes were added to cultures of LPS-stimulated monocytes from healthy seronegative individuals. The inhibitory effect of T cells required homotypic interactions between T cells and monocytes and was also observed by adding supernatants from PHA-stimulated T cells to monocytes in culture. Inhibition was not observed with purified CD8+ lymphocytes. Inhibition mediated by T cells was dependent on the induction of the production and release by monocytes of the functional inhibitor of IL-1, IL-1 Ra, as assessed by ELISA. Induction by T cells of IL-1 Ra release was not dependent on the production of TGF beta. These observations indicate that CD4+ T lymphocytes negatively regulate the activity of released IL-1 by stimulated monocytes and suggest that the loss of CD4 cells in HIV disease enhances the proinflammatory effects of IL-1 that is constitutively produced by monocytes of infected patients.

*CD4-Positive T-Lymphocytes/IMMUNOLOGY *HIV Infections/IMMUNOLOGY *Interleukin-1/METABOLISM *Sialoglycoproteins/SECRETION



 




Information in this article was accurate in November 30, 1993. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.