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Survival (S) impact of different factors in AIDS patients (pts): retrospective analysis (Meeting abstract).


Proc Annu Meet Am Soc Clin Oncol; 12:A21 1993. Unique Identifier :

Between February 1983 and November 1992, 387 AIDS pts according to CDC classification system were assisted al Fernandez Hospital and Huesped Foundation. 296/387 had opportunistic infections (OI), 67/387 had Kaposi's sarcoma (KS) and 16/387 had non-Hodgkin's lymphomas (NHL) as initial disease. Eight pts were inevaluable. Age, sex, performance status (PS) according ECOG criteria, AZT treatment and CD4 level were evaluated for the whole group and stage and antineoplastic systemic treatment were also considered for neoplasias. Results: 49/387 still alive (12.6%); median survival (MS) of the whole group: 7.75 m (r1-49+ m). By univariate analysis (T test, Haenszel-Mantel) PS, AZT treatment and CD4 level correlates with MS. Results are presented in a table. By multivariate analysis (multiple regression), PS and AZT were the most significant factors to predict MS. Conclusions: (1) PS and AZT have linear correlation with S; (2) MS of good prognosis pts (3 factors) is 13.23 m; (3) MS of bad prognosis pts (3 factors) is 4.07 m; (4) PS must be included in all studies of AIDS pts.

Acquired Immunodeficiency Syndrome/DRUG THERAPY/IMMUNOLOGY/ *MORTALITY *Cause of Death CD4-Positive T-Lymphocytes/IMMUNOLOGY Follow-Up Studies Human Leukocyte Count Retrospective Studies Survival Rate Zidovudine/THERAPEUTIC USE ABSTRACT


Information in this article was accurate in December 30, 1993. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.