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Brainstem toxoplasmosis in patients with acquired immunodeficiency syndrome.




 

J Neuroimaging. 1994 Apr;4(2):85-90. Unique Identifier : AIDSLINE

Brainstem involvement by Toxoplasma gondii is probably more common than other opportunistic infections, although it has not received adequate attention. Identification of toxoplasmosis is essential, as this condition responds to treatment with a significant increase in life expectancy. During the past 4 years, 366 AIDS patients with central nervous system toxoplasmosis diagnosed by biopsy or improvement following empirical treatment were evaluated. Among them, 8 (7 men, 1 woman; aged 25-55 yr) presented with signs of brainstem dysfunction. Six patients presented with an oculomotor nerve palsy and contralateral hemiplegia; 1 had an additional ipsilateral rubral tremor. The seventh patient had complete external ophthalmoplegia and the eighth had Parinaud's syndrome. Computed tomography revealed enhancing lesions in the brainstem of all patients. Seven responded to treatment with pyrimethamine and sulfadiazine.

Adult AIDS-Related Opportunistic Infections/*RADIOGRAPHY Brain/RADIOGRAPHY *Brain Stem/RADIOGRAPHY Female Human Male Middle Age Tomography, X-Ray Computed Toxoplasmosis, Cerebral/*RADIOGRAPHY JOURNAL ARTICLE



 




Information in this article was accurate in August 30, 1994. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.