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Human herpesvirus 6 DNA in blood cells of human immunodeficiency virus-infected men: correlation of high levels with high CD4 cell counts.




 

J Infect Dis. 1994 Jun;169(6):1342-5. Unique Identifier : AIDSLINE

The relationship between human herpesvirus 6 (HHV-6) and the progression of human immunodeficiency virus type 1 (HIV-1) infection to AIDS was evaluated using the polymerase chain reaction to quantitate HHV-6 genome equivalents in peripheral blood mononuclear cells (PBMC) and saliva of 32 HIV-1-seropositive men. Unlike other herpesviruses, HHV-6 was found with higher frequency and in higher copy numbers of HIV-infected men with high rather than low CD4 cell counts. Among subjects with > 400 CD4 cells/mL, 100% had detectable HHV-6 genomes in PBMC compared with 57.9% of subjects with < 400 CD4 cells/mL (P < .05). There was no significant correlation between HHV-6 antibody titer or number of amplifiable copies of HHV-6 DNA in saliva and stage of HIV disease or CD4 cell number.

Adult AIDS-Related Opportunistic Infections/IMMUNOLOGY/*MICROBIOLOGY CD4-Positive T-Lymphocytes/CYTOLOGY/*IMMUNOLOGY DNA, Viral/*BLOOD Herpesviridae Infections/*COMPLICATIONS/MICROBIOLOGY Herpesvirus 6, Human/GENETICS/*ISOLATION & PURIF Human Leukocyte Count Male Middle Age Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE



 




Information in this article was accurate in September 30, 1994. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.