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NLM AIDSLINE

[Immunocytophotometric and cytogenetic analyses of T-lymphoblastoid cell lines in experimental HIV Infection]




 

Vopr Virusol. 1994 Mar-Apr;39(2):77-80. Unique Identifier : AIDSLINE

The accumulation of viral proteins p24 and gp41 in MT-4 cells was shown to occur asynchronously. No increase in the number of polydiploid cells, no polyploid mitoses or chromosome defects were found indicating the antiproliferative effect of HIV on MT-4 cells. A cyclic pattern of the infection course was observed in infected Jurkat-tat cells. The accumulation of viral proteins was concerted, their maximum amounts preceding the cell death. HIV-1 did not inhibit cell division and caused strong disorders in the chromosome structure.

Acute Disease Cell Line Cells, Cultured/METABOLISM/MICROBIOLOGY *Chromosome Aberrations Comparative Study Cytopathogenic Effect, Viral Cytophotometry English Abstract Human HIV Core Protein p24/METABOLISM HIV Envelope Protein gp41/METABOLISM HIV Infections/GENETICS/METABOLISM/*MICROBIOLOGY HIV-1/*PATHOGENICITY Immunohistochemistry Polyploidy T-Lymphocytes/METABOLISM/*MICROBIOLOGY Time Factors JOURNAL ARTICLE



 




Information in this article was accurate in September 30, 1994. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.