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Synthesis of a new hydroxyethylene dipeptide isostere Phe psi [CH2CH (OH)]Phe as HIV-1 protease inhibitor.




 

Chung Kuo Yao Li Hsueh Pao. 1994 Jan;15(1):33-5. Unique Identifier :

A new type of pseudopeptide isostere exampled by Phe psi[CH2CH(OH)]Phe was synthesized from phenylalanine. The HIV protease inhibitory activity (IC50) of Noa-His-Phe psi[CH2CH(OH)]Phe-Ile-Amp was 0.8 pmol.L-1.

Dipeptides/CHEMISTRY/*CHEMICAL SYNTHESIS HIV Protease Inhibitors/CHEMISTRY/*CHEMICAL SYNTHESIS Structure-Activity Relationship JOURNAL ARTICLE



 




Information in this article was accurate in September 30, 1994. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.