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Induction of developmentally programmed cell death and activation of HIV by sodium butyrate.




 

Virology. 1994 Jul;202(1):513-8. Unique Identifier : AIDSLINE

Apoptosis is an important regulatory process during normal development and maturation. We find that the proliferation-arresting and differentiation-inducing compound sodium n-butyrate (NaB) triggers a marked host chromatin degradation. This apoptotic process is independent of, but commensurate with, a rapid increase in viral mRNA synthesis and subsequent release of HIV-1 virus in transformed human cell lines harboring tat- (HLM1) or tat+ (U1, ACH-2) dormant HIV-1 proviruses. This compound stimulates a reversible accumulation of the characteristic viral mRNAs at a much faster rate than two other DNA degradation inducers such as tumor necrosis factor-alpha and phorbol 12-myristate 13-acetate. The transcriptional activator butyrate analogue, alpha-amino-n-butyrate, failed to cause similar phenotypic changes. These results suggest that common regulatory signals may be involved in activation of apoptosis genes and latent provirus by NaB.

*Apoptosis Butyric Acids/*PHARMACOLOGY Cell Line Chromatin/DRUG EFFECTS Human HIV-1/*DRUG EFFECTS/GROWTH & DEVELOPMENT Kinetics RNA, Viral/BIOSYNTHESIS Virus Activation/DRUG EFFECTS JOURNAL ARTICLE



 




Information in this article was accurate in September 30, 1994. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.