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HIV-2 EHO isolate has a divergent envelope gene and induces single cell killing by apoptosis.


Virology. 1994 Jul;202(1):471-6. Unique Identifier : AIDSLINE

The human immunodeficiency virus type 2 (HIV-2)-related isolate, referred to as HIV-2 EHO, has been isolated from an Ivory Coast patient with acquired immunodeficiency syndrome (AIDS). Infection of CD4 expressing cells with this highly infectious virus mediates a cytopathic effect characterized by single-cell killing as a consequence of apoptosis. Nucleotide sequence analysis of the HIV-2 EHO genome revealed a significant degree of divergence of its envelope gene from that of other known HIV-2 strains. This divergence for the deduced amino acid sequence corresponding to the extracellular envelope glycoprotein was 26 to 30%. These unique genetic and biological properties suggest that the HIV-2 EHO isolate is a distinct prototype in the HIV-2 family.

Acquired Immunodeficiency Syndrome/MICROBIOLOGY Amino Acid Sequence *Apoptosis Cells, Cultured *Genes, env Giant Cells/MICROBIOLOGY Human HIV Envelope Protein gp120/GENETICS HIV-2/CLASSIFICATION/*GENETICS/PATHOGENICITY Molecular Sequence Data Sequence Homology, Amino Acid Support, Non-U.S. Gov't *Variation (Genetics) JOURNAL ARTICLE


Information in this article was accurate in September 30, 1994. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.