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Incidence and prevalence of human immunodeficiency virus, hepatitis B virus, hepatitis C virus, and cytomegalovirus among health care personnel at risk for blood exposure: final report from a longitudinal study [see comments]


J Infect Dis. 1994 Dec;170(6):1410-7. Unique Identifier : AIDSLINE

In a 10-year dynamic cohort study, 976 health care providers were followed a mean of 1.9 years to evaluate the risk of human immunodeficiency virus (HIV) transmission, delayed seroconversion, and seronegative latent infection following occupational exposures. The seroprevalence and incidence of HIV, hepatitis B virus (HBV), hepatitis C virus (HCV), and cytomegalovirus (CMV) infection were also measured, with annual serologic testing for viruses and postexposure HIV tests. One of 327 percutaneous exposures (0.31%; confidence interval, 0.008%-1.69%) and 0 of 398 mucocutaneous exposures to HIV-infected blood transmitted HIV. Neither delayed seroconversions nor seronegative latent infections were detected. The baseline seroprevalences of HBV, HIV, HCV, and CMV infection were 21.7%, 0, 1.4%, and 43.4%, respectively. Corresponding incidence density rates were 3.05, 0.055, 0.08, and 2.48 (per 100 person-years). Despite infection control precautions and availability of hepatitis B vaccine, these health care providers remain at risk for acquiring bloodborne viral infections.

Blood/VIROLOGY *Blood-Borne Pathogens Cohort Studies Comparative Study Cytomegalovirus Infections/*EPIDEMIOLOGY Female HIV Infections/*EPIDEMIOLOGY/TRANSMISSION *Health Personnel Hepatitis B/*EPIDEMIOLOGY Hepatitis C/*EPIDEMIOLOGY Human Incidence Longitudinal Studies Male *Occupational Exposure Prevalence San Francisco/EPIDEMIOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE


Information in this article was accurate in March 30, 1995. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.