J Infect Dis. 1994 Dec;170(6):1410-7. Unique Identifier : AIDSLINE
In a 10-year dynamic cohort study, 976 health care providers were
followed a mean of 1.9 years to evaluate the risk of human
immunodeficiency virus (HIV) transmission, delayed seroconversion, and
seronegative latent infection following occupational exposures. The
seroprevalence and incidence of HIV, hepatitis B virus (HBV), hepatitis
C virus (HCV), and cytomegalovirus (CMV) infection were also measured,
with annual serologic testing for viruses and postexposure HIV tests.
One of 327 percutaneous exposures (0.31%; confidence interval,
0.008%-1.69%) and 0 of 398 mucocutaneous exposures to HIV-infected blood
transmitted HIV. Neither delayed seroconversions nor seronegative latent
infections were detected. The baseline seroprevalences of HBV, HIV, HCV,
and CMV infection were 21.7%, 0, 1.4%, and 43.4%, respectively.
Corresponding incidence density rates were 3.05, 0.055, 0.08, and 2.48
(per 100 person-years). Despite infection control precautions and
availability of hepatitis B vaccine, these health care providers remain
at risk for acquiring bloodborne viral infections.
Blood/VIROLOGY *Blood-Borne Pathogens Cohort Studies Comparative
Study Cytomegalovirus Infections/*EPIDEMIOLOGY Female HIV
Infections/*EPIDEMIOLOGY/TRANSMISSION *Health Personnel Hepatitis
B/*EPIDEMIOLOGY Hepatitis C/*EPIDEMIOLOGY Human Incidence
Longitudinal Studies Male *Occupational Exposure Prevalence San
Francisco/EPIDEMIOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't,
P.H.S. JOURNAL ARTICLE