Resource Logo
NLM AIDSLINE

The dual-function hamster receptor for amphotropic murine leukemia virus (MuLV), 10A1 MuLV, and gibbon ape leukemia virus is a phosphate symporter.




 

J Virol. 1995 Jan;69(1):534-7. Unique Identifier : AIDSLINE MED/95074910

Previously, we showed that the amphotropic receptor homolog in hamster cells functions as a receptor not only for amphotropic murine leukemia viruses and 10A1 murine leukemia virus but also for gibbon ape leukemia virus (C.A. Wilson, K. B. Farrell, and M. V. Eiden, J. Virol. 68:7697-7703, 1994). Here, we demonstrate that this receptor functions as a sodium-dependent Pi transporter and that Na-Pi uptake can be specifically blocked following infection with either amphotropic murine leukemia virus, 10A1 murine leukemia virus, or gibbon ape leukemia virus.

Animal Biological Transport Carrier Proteins/METABOLISM Hamsters Human Leukemia Virus, Gibbon Ape/GENETICS/*METABOLISM Leukemia Viruses, Murine/GENETICS/*METABOLISM Phosphates/*METABOLISM Receptors, Virus/*METABOLISM Sodium/METABOLISM JOURNAL ARTICLE



 




Information in this article was accurate in March 30, 1995. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.