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Liposomes as carriers for vaccines.


Immunomethods. 1994 Jun;4(3):217-22. Unique Identifier : AIDSLINE

A liposome vaccine formulation that has been successfully used in both animal immunization studies and clinical trials is described. Issues concerning the choice of components for the liposomal vaccine formulation are discussed, especially with respect to the lipid components and the adjuvant. A procedure is described for manufacturing liposomal vaccines using Good Manufacturing Practices as promulgated by the U.S. Food and Drug Administration. Quality control testing for clinical use is described, with particular emphasis on aspects relevant to liposomes. Utilization issues are discussed, including injection volumes, antigen and adjuvant doses, and routes of administration.

Adjuvants, Immunologic Alum Compounds Animal AIDS Vaccines/ADMINISTRATION & DOSAGE Clinical Trials Drug Compounding Haplorhini Human Injections, Intramuscular Injections, Intravenous Lipid A/IMMUNOLOGY *Liposomes/ADMINISTRATION & DOSAGE/CHEMISTRY/PHARMACOKINETICS Malaria Vaccines/ADMINISTRATION & DOSAGE Mice Plasmodium falciparum/IMMUNOLOGY Quality Control Rabbits Safety SAIDS Vaccines/ADMINISTRATION & DOSAGE Vaccination/METHODS *Vaccines/ADMINISTRATION & DOSAGE JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL


Information in this article was accurate in April 30, 1995. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.