seroprevalence and incidence of sexually transmitted diseases in a rural ugandan population.

NLM AIDSLINE Seroprevalence and incidence of sexually transmitted diseases in a rural Ugandan population. Wagner HU; Van Dyck E; Roggen E; Nunn AJ; Kamali A; Schmid DS; Dobbins
April 30, 1995

Int J STD AIDS. 1994 Sep-Oct;5(5):332-7. Unique Identifier : AIDSLINE The aim of the study was to determine in a rural population the age- and sex-specific prevalence and incidence rates of serological reactivity of 5 common sexually transmitted diseases (STDs) and their association with HIV-1 antibody status. Of the adult population of two villages (529 adults aged 15 years or more) 294 provided an adequate blood specimen both on enrollment and at 12 months. The sera were tested at 3 collaborating laboratories for antibodies against HIV-1, Treponema pallidum, Haemophilus ducreyi, Chlamydia trachomatis and herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2). A sample of 45 children were tested for HSV-1 and HSV-2. Seroprevalence rates in adults on enrollment were 7.8% for HIV-1, 10.8% for active syphilis, 10.4% for H. ducreyi, 66.0% for C. trachomatis, 91.2% for HSV-1 and 67.9% for HSV-2. Males were significantly more likely than females to be seropositive for H. ducreyi (15.6% versus 6.6%), but less likely to be HSV-2 antibody positive (57.0% versus 74.4%). Reactivity to H. ducreyi, C. trachomatis and HSV-2 rose with increasing age. In contrast, active syphilis showed no age trend. All STDs tended to be more common in those HIV-1 seropositive. Incidence rates over the 12 months were nil for HIV-1, 0.5% for syphilis, 1.2% for H. ducreyi, 11.3% for C. trachomatis, and 16.7% for HSV-2. The results of this exploratory study indicate that all STDs included are common in this rural population. The high HSV-2 prevalence rate among adolescents suggests that HSV-2 may be an important risk factor for HIV-1 infection.(ABSTRACT TRUNCATED AT 250 WORDS) Adolescence Adult Age Factors Child Child, Preschool Comorbidity Female Human HIV Seropositivity/BLOOD/COMPLICATIONS/EPIDEMIOLOGY/TRANSMISSION HIV Seroprevalence HIV-1 Incidence Infant Male Population Surveillance Prevalence Prospective Studies Risk Factors Rural Population Seroepidemiologic Methods Sex Factors Sexually Transmitted Diseases/BLOOD/COMPLICATIONS/EPIDEMIOLOGY/ TRANSMISSION Support, Non-U.S. Gov't Uganda/EPIDEMIOLOGY JOURNAL ARTICLE

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Information in this article was accurate in April 30, 1995. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.