Ear Nose Throat J. 1994 Oct;73(10):772-4, 777-8. Unique Identifier :

Malignant otitis externa is a necrotizing infection of the external ear canal and surrounding soft tissue and bone, usually caused by Pseudomonas aeruginosa. The infection classically occurs in diabetic patients, however recently, several patients with the acquired immunodeficiency syndrome (AIDS) have been reported to have malignant otitis externa. A patient with AIDS who had malignant otitis externa with skull base osteomyelitis is presented and reported cases in patients with AIDS are reviewed. Predisposing factors include immunologic abnormalities (notably neutropenia), dermatitis, medications, neoplasm, and iatrogenic procedures, e.g., ear lavage. Treatment of malignant otitis externa has traditionally included anti-pseudomonal cephalosporins/penicillins and aminoglycosides for prolonged durations. Recently, ciprofloxacin has been shown to be effective as an oral regimen. With the increasing number of patients with AIDS being seen in the outpatient clinics, the diagnosis of malignant otitis externa should be considered in any patient with persistent ear pain or otorrhea who does not respond to conventional treatment for external otitis.

Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult Antibiotics/THERAPEUTIC USE Bone Diseases/PATHOLOGY Case Report Ciprofloxacin/ADMINISTRATION & DOSAGE/THERAPEUTIC USE Human Male Otitis Externa/*COMPLICATIONS/DRUG THERAPY/*MICROBIOLOGY Pseudomonas aeruginosa/*ISOLATION & PURIF Skull/PATHOLOGY JOURNAL ARTICLE